the default loop looks as this :
<?php if ( have_posts() ) : while ( have_posts() ) : the_post(); ?>
In case you want to display posts in many layouts , you can use counter to identfy the frist post .
and get it layout and the second post
<?php
if (have_posts()) : while (have_posts()) : the_post();
if (++$counter == 1) {
// Code for first post here
} else {
// Code for other posts here
} endwhile; else :
// Code for no posts found here
endif; ?>